for Healthcare professionals: PROCAINAMIDE HYDROCHLORIDE, Vial U.S. structure of a molecule an d its biological activity. One of such options is procainamide as demonstrated its effectiveness in N-glycan analyses elsewhere, which uses the same chemistry as 2-AB labels the reducing end of glycans via reductive 10.0amination. Indicated in SVT and ventricular tachycardia (V-tach). 12/5/2016Clinical Pharmacokinetics of procainamide by Behailu & Bezie Methods to administer procainamide LD. Indication : Ventricular arrhythmias Clinical Use Procainamide hydrochloride is metabolized through theaction of N-acetyltransferase. Other names: Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-; . A:Infrared Absorption á 197K ñ. DG00193 Procainamide. It also prolongs the action potential and reduces the speed of impulse conduction. Procainamide hydrochloride | C13H22ClN3O - PubChem compound Summary Procainamide hydrochloride Contents 1 Structures 2 Names and Identifiers 3 Chemical and Physical Properties 4 Related Records 5 Chemical Vendors 6 Drug and Medication Information 7 Pharmacology and Biochemistry 8 Use and Manufacturing 9 Safety and Hazards 10 Toxicity 11 Literature Atomic resolution structural analysis can be obtained using methods such as X-ray crystallography and multi-dimensional NMR spectroscopy , but typically involve considerable costs, time, and expertise. 1) administers 100 mg q5` to a maximum of 500 mg; a 10 minute waiting period to allow drug distribution to tissues is utilized if more than 500 mg is needed to abate the arrhythmia. Procainamide. Fabrication of cyclodextrins-procainamide supramolecular self-assembly: Shape-shifting of nanosheet into microtubular structure May 2015 Carbohydrate Polymers 122 Procainamide hydrochloride (PAH) is suitable to investigate its binding behavior with human serum albumin and bovine serum albumin by fluorescence quenching study to understand the pharmacokinetic and pharmacodynamic mechanisms of PAH. For research use only. This Thermo Scientific brand product was originally part of the Acros Organics product portfolio. ChE;DNA (cytosine-5)-methyltransferase 1 ;Sodium channel TargetMol T0018: Membrane Transporter/Ion Channel; Neuroscience; Chromatin/Epigenetic TargetMol T0018: Others MedChem Express HY-A0084: Procainamide hydrochloride is an anti-arrhythmic agent and is used to treat cardiac arrhythmia; induces rapid block of the batrachotoxin(BTX)-activated sodium channels of the heart muscle and acts as . Procainamide Hydrochloride Injection, USP is a sterile, nonpyrogenic solution of procainamide hydrochloride in water for injection. In this article, the structure of (I) was redetermined with better R-factors (R1 = 5.1%, wR2 = 14.4%) because of resolution of the N-2-diethylaminoethyl moiety disorder. History The patient who is taking quinidine might develop hypotension, QT prolongation, and anorexia. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific. Samples were cleaned up using . Chemical formula: C13H21N3O Drugbank ID: DB01035 ATC code(s): C01BA02. Biochem/physiol Actions Procainamide hydrochloride is a sodium channel blocker and Class IA anti-arrhythmic. The product of enzymaticmetabolism of procainamide hydrochloride is N-acetylprocainamide(NAPA), which possesses only 25% of the activityof the parent compound.26 A study of the disposition ofprocainamide hydrochloride showed that 50% of the drugwas excreted unchanged in the urine, with 7% to 24% . Download . inhibitor procainamide were fused in Proca-SAHA (compound 4, Scheme 1). It is most commonly used in dental procedures to numb the area around a tooth and is also used to reduce the pain of intramuscular injection of penicillin.Owing to the ubiquity of the trade name Novocain, in some regions, procaine is referred to generically as novocaine.It acts mainly as a sodium channel blocker. D00477 Procainamide hydrochloride (JP18/USP) Drug groups [BR: br08330] Cardiovascular agent. Formula: C 13 H 21 N 3 O; Molecular weight: 235.3253; . Procainamide is a Vaughan Williams Class 1 sodium channel blocker with the structure shown below. Chemical structure : Tradename : Trade names are indicative and excipients composition can be different depending on the country and manufacturers . 76329-3399-5 - 5 SYRINGE in 1 PACKAGE ; The NDC Directory contains ONLY information on final marketed drugs submitted to FDA electronically by labelers. Metabolizing enzyme substrate. Procanbid, Pronestyl (procainamide) is a small molecule pharmaceutical. Copy Sheet of paper on top of another sheet. Procainamide and its metabolite N -acetyl procainamide also exert potassium efflux channel blocking effects prolonging the QT interval. Procainamide HCl (Pronestyl) iii. Procainamide. Procainamide | C13H21N3O - PubChem compound Summary Procainamide Contents 1 Structures 2 Names and Identifiers 3 Chemical and Physical Properties 4 Spectral Information 5 Related Records 6 Chemical Vendors 7 Drug and Medication Information 8 Pharmacology and Biochemistry 9 Use and Manufacturing 10 Identification 11 Toxicity Encapsulation behavior of α- and β-cyclodextrins (α-CD, β-CD) with procainamide hydrochloride (PCA) has been investigated by absorption, fluorescence, time-resolved fluorescence, proton nuclear magnetic resonance spectroscopy, scanning electron microscope, Fourier transform-infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffraction techniques. Procainamide Mechanism : It is an amide derivative of procaine used in the treatment of atrial and ventricular arrhythmias. A device for vaporizing a composition. Procainamide is an antiarrhythmic agent used to suppress ventricular tachydysrhythmias. A benzamide that is 4-aminobenzamide substituted on the amide N by a 2- (diethylamino)ethyl group. Click to enlarge. • The analysis of the dependence of . Aliquots of 5μL of free reducing end glycans were labelled with procainamide using the LudgerTag Proc labelling kit, 20 μL of labelling solution was added (procainamide-HCl 0.2 M, acetic acid: DMSO: water, (1.5:3.5:5), NaCNBH 3 0.5M) briefly vortexed and incubated for 1 h at 65 °C. The chemical reaction between procainamide hydrochloride and glucose following admixture to glucose infusion has been investigated. The structure of procainamide hydrochloride has been reported earlier with the refcode according to CSD version 5.29, 2007: ETBZCL . Procainamide hydrochloride is an anti-arrhythmic agent and is used to treat cardiac arrhythmia; induces rapid block of the batrachotoxin (BTX)-activated sodium channels of the heart muscle and acts as antagonist to long gating closures. Procainamide. Procainamide hydrochloride [USP:JAN] View Synonyms View Structure: Description: A benzoic-sulfonamide-furan. Files are available under licenses specified on their description page. A labeler might be a manufacturer, re-packager or re-labeler. . Formula: C 13 H 21 N 3 O. Molecular weight: 235.3253. Proc West Pharmacol Soc. Tel. D00477 Procainamide hydrochloride. Procainamide (proe kane' a mide) is an analogue of the local anesthetic procaine and has electrophysiological effects that resemble quinidine. Procainamide. PROCAINAMIDE HYDROCHLORIDE (procainamide hydrochloride) This product information is intended only for residents of the United States. Description. Procainamide - cas 51-06-9, synthesis, structure, density, melting point, boiling point Human systemic effects by ingestion: agranulocytosis, thrombocytopenia, leukopenia, joint effects. A derivative of procaine with less CNS action. It is used to treat atrial fibrillation, atrial flutter, cardiac arrhythmias, supraventricular tachycardia, and ventricular premature complexes amongst others in the USA. Procainamide: 9.43: Structure Format CFG/Essentials Text Oxford Oxford Color CFG Oxford Hybrid. These are aromatic carboxylic acid derivatives consisting of an amide with a benzamide moiety and a triethylamine attached to the amide nitrogen. PHYSICO-CHEMICAL PROPERTIES 3.1 Origin of the substance Synthetic chemical 3.2 Chemical structure Structural formula Molecular formula Procainamide C 13 H 22 ClN 3 O Procainamide C 13 H 22 ClN 3 0,HCl hydrochloride Molecular weight: Procainamide 325.5 Procainamide 271.8 hydrochloride Chemical names 4-Amno-N-(2-diethylaminoethyl)benzamide . 32. Pronestyl United States of America Compatibility : Procainamide hydrochloride : This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility . 1981;24:221-4. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. 614-39-1 - ABTXGJFUQRCPNH-UHFFFAOYSA-N - Procainamide hydrochloride [USP:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information. This entity has been manually annotated by the ChEBI Team. The patient who is taking flecainide might experience dizziness and visual disturbances. 114. A class IA antiarrythmic. The first way consists of the direct reaction of the 4-aminobenzoic acid ethyl ester with 2-diethylaminoethanol in the presence of sodium ethoxide. lupus-like symptoms--joint pain or swelling, stomach pain, chest pain, shortness of breath, and a rash or patchy skin color that worsens in sunlight. 112. These reagents are Procainamide appears to act by blocking open sodium channels and outward potassium channels. The N-glycan identification results analyzed by procainamide labeling and LC-ESI-MS/MS, and 2-AB labeling and HILIC-UPLC showed that the predominant forms were fucosylated bi-antennary structures containing 0, 1, or 2 terminal galactose residues (i.e., G0F, G1F, and G2F) and an afucosylated bi-antennary structure with no terminal galactose (i.e . The MarketWatch News Department was not involved in the creation of this content. Some documentation and label information may refer to the legacy brand. Procainamide labelling. Procainamide is pharmacokinetically dosed with a therapeutic range between 4-12mcg/ml. Chemical structure and specific uses of Amyl nitrate. Procainamide hydrochloride Chemical Structure. USP Procainamide Hydrochloride RS . IUPAC Standard InChI: InChI=1S/C13H21N3O/c1-3-16 (4-2)10-9-15-13 (17)11-5-7-12 (14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3, (H,15,17) Copy Sheet of paper on top of another sheet. This action results in decreased myocardial excitability, slowed conduction velocity, and reduced myocardial contractility. Test solution— Dilute the Test solution, prepared as . 12/5/2016Clinical Pharmacokinetics of procainamide by Behailu & Bezie Methods to administer procainamide LD. : 410-614-1661; Fax: 410-502-9817. What is the nurse's best response? Table 1 Procainamide-derivatised disaccharide structure and MS ions observed using optimum derivatisation conditions Full size table The effect of derivatisation reagent (procainamide hydrochloride) concentration on LC-peak area was studied (ESM, Fig. Abstract. Procainamide is a class 1a antiarrhythmic agent whose primary mechanism is related to its antagonism of cardiac sodium channels delaying phase 0 of the cardiac cycle. Procainamide (µmol/L) 0 4.3 8.5 17 34 68 1 INtENDED USE The Emit® 2000 Procainamide Assay is a homogeneous enzyme immunoassay intended for use in the quantitative analysis of procainamide in human serum or plasma. It is most commonly used in dental procedures to numb the area around a tooth and is also used to reduce the pain of intramuscular injection of penicillin.Owing to the ubiquity of the trade name Novocain, in some regions, procaine is referred to generically as novocaine.It acts mainly as a sodium channel blocker. Here, to provide another option for labeling the O-glycans with EZGlyco O-Glycan Prep Kit, we adapted procainamide in place DG01652 Class I antiarrhythmic agent. Compounds 4 and 5 were directly synthesized from procainamide 1 after coupling with methyl 6-chloro-6-oxohexanoate or methyl-8-chloro-8-oxooctanoate followed by treatment with hydroxylamine in the presence of sodium hydroxide. Procaine, the 2-diethylaminoethyl ester of 4-aminobenzoic acid (2.1.1), better known as novocaine, is synthesized in two ways. The surface structure is configured to form liquid droplets of the . Procanbid, Pronestyl (procainamide) is a small molecule pharmaceutical. D08421 Procainamide. Biocoryl is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. ref. This page was last edited on 15 August 2020, at 04:01. Disopyramide Phosphate (Norpace, Regubeat) iv. The pharmaceuticals, procaine hydrochloride and procainamide hydrochloride, are glass-forming as well as ionically conducting materials. Procan ® Structure. Write the structure and specific uses of quinidine 116. The health care provider discontinues a patient's quinidine and prescribes procainamide. Absorption 75 to 95% Volume of distribution 2 L/kg Protein binding 15 to 20% Metabolism Hepatic